Neuroprotective and Cognative Preformance.
Not to be taken if on SSRI's. Boosts Seretonin
Men 30 Clicks Daily
Women 20 Clicks Daily
 
Astressin-B is a synthetic peptide and a non-selective corticotropin-releasing factor (CRF) receptor antagonist, known for its ability to block CRF1 and CRF2 receptors involved in stress responses. 
 
Benefits of Astressin-B Peptide
1.  Hair Growth and Alopecia Prevention:
    •  Promotes Hair Regrowth: Astressin-B has shown significant potential in stimulating hair regrowth in animal studies, particularly in stress-induced alopecia models. In CRF-overexpressing mice, daily injections (5 µg/mouse for 5 days) led to robust hair regrowth and pigmentation that lasted over 4 months, suggesting it may counteract stress-related hair loss.
    •  Prevents Hair Loss: In young mice not yet showing alopecia, Astressin-B prevented hair loss onset, indicating potential prophylactic use.
    •  Darker Hair Pigmentation (Grey Hair Reversal): It may enhance hair pigmentation, resulting in darker, healthier-looking hair compared to the original.
    •  Commercial Use: Incorporated into topical products like DS Laboratories’ Spectral.F7, Astressin-B is used to combat stress-induced hair thinning and promote follicular health, often as a booster alongside treatments like minoxidil.
 
2.  Stress-Related Symptom Relief:
    •  Reduces Stress-Induced Hormonal Effects: Astressin-B blocks CRF receptors, reducing the synthesis of adrenocorticotropic hormone (ACTH) and cortisol, which are elevated during stress. This may mitigate stress-related physiological effects, such as adrenal gland hyperactivity or immune suppression.
    •  Improves Sexual Drive: Astressin-B can improve sexual drive, suggesting potential benefits for stress-related reproductive dysfunction.
    •  Reverses Stress Effects on the Brain: Astressin-B has reversed chronic stress-induced changes in GABA-A receptor binding in the prefrontal cortex, potentially improving mood and cognitive function.
 
3.  Gastrointestinal Health:
    •  Delays Gastric Emptying: Astressin-B can delay gastric emptying, which may help manage stress-related gastrointestinal disorders like irritable bowel syndrome (IBS) by reducing visceral discomfort and motility disturbances.
    •  Reduces Visceral Pain: When injected intracerebrally, Astressin-B reduces CRF-induced visceral discomfort, suggesting potential for IBS symptom relief.
 
4.  Reproductive Health:
    •  Restores Luteal Function: Astressin-B prevented the inhibitory effect of ghrelin on luteinizing hormone (LH) pulse frequency, supporting normal reproductive function during stress or energy deficits.
    •  Protects Against Stress-Induced Dysfunction: It mitigates stress-related suppression of the hypothalamic-pituitary-adrenal (HPA) and gonadal axes, potentially aiding fertility and hormonal balance.
 
5.  Neuroprotective Effects:
    •  Hippocampal Protection: Astressin-B has been shown to be neuroprotective in the hippocampus when administered after seizures, potentially reducing neuronal damage and supporting brain health.
 
* Astressin B calms the Central Nervous System and improves mood.
 
6.  Potential for Anxiety and Depression Management:
    •  By antagonizing CRF receptors, which are linked to anxiogenic (anxiety-inducing) responses, Astressin-B may help reduce symptoms of anxiety and depression, though clinical trials are needed.
 
Semax Peptide Benefits
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro), an analog of ACTH (4-10), developed in Russia and used primarily for its nootropic, neuroprotective, and neurotrophic effects. It is approved in Russia for certain medical uses but is considered a research peptide elsewhere.
1.  Enhanced Cognitive Function:
    •  Improved Memory and Learning: Semax increases brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression, enhancing memory consolidation, learning capacity, and attention, particularly under stress.
    •  Cognitive Performance: Used by students, professionals, and athletes to boost mental clarity, focus, and cognitive processing speed.
2.  Neuroprotection and Recovery:
    •  Stroke and Brain Injury: Semax accelerates recovery from ischemic stroke and traumatic brain injury by promoting neuronal survival, reducing inflammation, and enhancing neuroplasticity. It’s used clinically in Russia for stroke rehabilitation.
    •  Neurodegenerative Protection: May protect against Alzheimer’s, Parkinson’s, and other neurodegenerative diseases by reducing oxidative stress and supporting neuronal repair.
 
3.  Mood and Stress Regulation:
    •  Anxiolytic Effects: Semax exhibits anti-anxiety properties without sedation, likely by modulating serotonin, dopamine, and enkephalin levels, improving mood and emotional resilience.
    •  Stress Resistance: Enhances adaptation to stress by normalizing HPA axis activity and reducing stress-induced behavioral changes.
 
4.  Pain Management:
    •  Increases enkephalin levels, which inhibit pain signal transmission, potentially reducing pain perception without opioid-like addiction risks.
 
5.  Improved Energy and Motivation:
    •  Boosts dopamine and serotonin signaling, enhancing motivation, energy, and productivity, making it popular for combating fatigue or brain fog. (Not recommedend if taking SSRI's - antidepressants)
 
6.  Ophthalmic and Vascular Benefits:
    •  Eye Health: Approved in Russia for treating optic nerve atrophy and glaucomatous optic neuropathy by improving retinal blood flow and protecting optic nerves.
    •  Cerebral Blood Flow: Enhances microcirculation in the brain, supporting cognitive and neurological health.
 
7.  Immune and Anti-Inflammatory Effects:
    •  Modulates immune responses and reduces inflammation, potentially aiding in recovery from infections or inflammatory conditions.
 
Potential Synergy of Astressin-B and Semax
 
•  Stress Reduction: Astressin-B’s CRF receptor antagonism reduces stress-induced cortisol and HPA axis overactivity, while Semax enhances stress resilience via neurotransmitter modulation, potentially amplifying mood and cognitive benefits.
 
•  Neuroprotection: Both peptides protect neurons—Astressin-B in the hippocampus and Semax broadly across the brain—potentially enhancing recovery from neurological insults.
 
•  Hair and Systemic Health: Astressin-B’s hair regrowth effects could complement Semax’s systemic benefits (e.g., improved energy, immunity), supporting overall wellness in stress-related conditions.