NAD precusor
Best taken with NR
 
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule and nicotinamide N-methyltransferase (NNMT) inhibitor that has gained attention for its potential in weight loss, metabolic health, and anti-aging. It works by blocking NNMT, an enzyme involved in fat storage and energy metabolism, and increasing NAD+ levels, which supports cellular energy and longevity pathways. 
 
Benefits of 5-Amino-1MQ
 
1.  Weight Loss and Fat Reduction:
    •  Fat Metabolism: Inhibits NNMT, reducing fat cell size and promoting lipolysis (fat breakdown). Studies in mice showed a 47% reduction in fat mass and up to 7% body weight loss in 10 days without appetite suppression. Human anecdotal reports suggest significant reductions in visceral fat when combined with diet and exercise.
    •  Increased Basal Metabolic Rate (BMR): Enhances energy expenditure, helping burn calories more efficiently, even at rest.
 
2.  Improved Metabolic Health:
    •  Insulin Sensitivity: Improves glucose uptake and reduces insulin resistance, potentially benefiting type 2 diabetes and metabolic syndrome.
    •  Cholesterol Management: Reduces total cholesterol (30% lower in treated mice) and lipogenesis (50–70% reduction in fat cells), supporting cardiovascular health.
 
3.  Anti-Aging and Cellular Health:
    •  NAD+ Boost: Increases nicotinamide adenine dinucleotide (NAD+) levels, activating SIRT1 (the “longevity gene”), which supports DNA repair, reduces inflammation, and enhances cellular resilience.
    •  Mitochondrial Function: Enhances energy production and mitochondrial health, combating age-related decline and fatigue.
 
4.  Muscle Health and Regeneration:
    •  Muscle Preservation: Prevents muscle wasting, particularly in aging or medical conditions like Duchenne Muscular Dystrophy, by promoting muscle stem cell activity and regeneration.
    •  Exercise Performance: Increases energy levels and endurance, aiding athletes in recovery and performance.
 
5.  Potential Anticancer Effects:
    •  Cancer Cell Inhibition: May reduce cancer cell proliferation by increasing NAD+ and altering lipid profiles (e.g., PAHSAs, which have anti-diabetic and anti-inflammatory effects). Preclinical studies suggest potential in gastric, pancreatic, and bladder cancers, though human data is limited.
    •  Chemotherapy Support: May enhance chemotherapy efficacy and reduce side effects by protecting healthy cells.
 
6.  Cognitive and Neurological Benefits:
   •  Brain Health: Increases NAD+ levels in the brain, potentially improving synaptic transmission and cognitive function. It may act as a nootropic, enhancing focus and mental clarity, though human studies are lacking.
 
7.  Convenient Administration and Safety:
    •  Forms: Available as oral capsules (50–100 mg, 1–3 times daily, often with meals) or subcutaneous injections.